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Defense Buff directly reduces the impact of enemies attack against you; Defense lowers the number of wounded you will have vs all 3 types of attack.

Health Buff is your “life.” Once The enemy attack has been countered by your defense, the amount of Health you have determines how many troops are actually wounded in battle.

- Because Defense Stats are generally much higher than Health, the Defense reach a point of limited return. In general,  increase to Health Stats help you more than Defense Stats . Think about that for runes, Talent Trees and equipment.

https://www.youtube.com/watch?v=-ZsW3qIFSnU